Registration of Confocal Fluorescence Endomicroscopy Images Using Phase Correlation

The emerging confocal fluorescence endomicroscope is capable of imaging living tissues in a non-invasive way using a probe to continuously scan the surface and subsurface tissue structures. Due to possible tissue movement and tissue expansion/contraction, the acquired images contain various noises and distortions. It is necessary to align these images in order to obtain a better 3D reconstruction of the tissue’s microstructure for clinicians. In this paper, we present an automatic image registration method using the phase correlation technique, which uses a fast frequencydomain approach to estimate the relative transformation parameters between two consecutive endomicroscopy images.